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High resolution pipette

United States Patent

June 7, 2016
View the Complete Patent at the US Patent & Trademark Office
A pipette includes a movable piston and a diaphragm that at least partly defines a fluid chamber enclosing a volume of working fluid. The piston displaces a volumetric amount of the working fluid in the chamber when moved. In response, the diaphragm displaces a smaller volumetric amount of fluid outside the chamber. A deamplification ratio is defined by the ratio of the volume displaced by the diaphragm to the volume displaced by the piston. The deamplification ratio is adjustable by adjusting or changing the diaphragm and/or by adjusting the size of the fluid chamber. The deamplifying pipette enables measuring and dispensing of very small volumes of liquid and is easily adapted to commercially available pipette components. Pipette components such as a pipette tip or adaptor may include a diaphragm to enable deamplification of the nominal volume capacity of a given pipette device.
Beroz; Justin Douglas (Ann Arbor, MI), Hart; Anastasios John (Ann Arbor, MI)
The Regents of the University of Michigan (Ann Arbor, MI)
13/ 873,962
April 30, 2013
STATEMENT REGARDING FEDERALLY-SPONSORED RESEARCH This invention was made with government support under DE-SC0004927 awarded by the Department of Energy. The government has certain rights in the invention.