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Over-expression of a putative oxidoreductase (UcpA) for increasing furfural or 5-hydroxymethylfurfural tolerance

United States Patent

9,347,077
May 24, 2016
View the Complete Patent at the US Patent & Trademark Office
The subject invention pertains to overexpression of a putative oxidoreductase (ucpA) for increasing furfural tolerance in genetically modified microorganisms. Genetically modified microorganisms capable of overexpressing UcpA are also provided. Increased expression of ucpA was shown to increase furfural tolerance by 50%, and to permit the fermentation of sugars to products in the presence of 15 mM furfural.
Wang; Xuan (Tempe, AZ), Miller; Elliot N. (Indianapolis, IN), Yomano; Lorraine P. (Gainesville, FL), Shanmugam; Keelnatham T. (Gainesville, FL), Ingram; Lonnie O'Neal (Gainesville, FL)
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, FL)
14/ 131,468
20140212933
July 9, 2012
This invention was made with government support under DE-FG36-08GO88142 awarded by Department of Energy and under 2001-10006-30358 awarded by the Department of Agriculture. The government has certain rights in the invention.