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Hybrid polyketide synthases

United States Patent

9,334,514
May 10, 2016
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
Fortman; Jeffrey L. (San Francisco, CA), Hagen; Andrew (Berkeley, CA), Katz; Leonard (Oakland, CA), Keasling; Jay D. (Berkeley, CA), Poust; Sean (Berkeley, CA), Zhang; Jingwei (San Francisco, CA), Zotchev; Sergey (Trondheim, NO)
The Regents of the University of California (Oakland, CA)
13/ 882,099
20130280766
October 31, 2011
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and Award No. 0540879 awarded by the National Science Foundation. The government has certain rights in the invention