The application describes therapeutic compositions and methods for treating cancer. For example, therapeutic compositions and methods related to inhibition of FAM83A (family with sequence similarity 83) are provided. The application also describes methods for diagnosing cancer resistance to EGFR inhibitors. For example, a method of diagnosing cancer resistance to EGFR inhibitors by detecting increased FAM83A levels is described.
STATEMENT REGARDING FEDERALLY SPONSORED R&D
This work was supported by Grant No. CA064786 awarded by the National Institutes of Health and the National Cancer Institute, Grant No. DAMD17-02-1-0441 awarded by the Department of Defense, and by Contract No. DE-AC02-05CH11231 awarded by the Department of Energy. The government has certain rights in the invention.