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Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation

United States Patent

April 5, 2016
View the Complete Patent at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.
Schaff; Ulrich Y. (Livermore, CA), Koh; Chung-Yan (Dublin, CA), Sommer; Gregory J. (Livermore, CA)
Sandia Corporation (Albuquerque, NM)
14/ 597,601
January 15, 2015
STATEMENT REGARDING RESEARCH & DEVELOPMENT This invention was developed under Contract DE-AC04-94AL85000 between Sandia Corporation and the U.S. Department of Energy. The U.S. Government has certain rights in this invention.