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Cytosolic delivery of materials with endosome-disrupting colloids

United States Patent

March 15, 2016
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A facile procedure to deliver nanocrystals to the cytosol of live cells that is both rapid and general. The technique employs a unique cationic core-shell polymer colloid that directs nanocrystals to the cytosol of living cells within a few hours of incubation. The present methods and compositions enable a host of advanced applications arising from efficient cytosolic delivery of nanocrystal imaging probes: from single particle tracking experiments to monitoring protein-protein interactions in live cells for extended periods.
Helms; Brett A. (San Francisco, CA), Bayles; Andrea R. (New Canaan, CT)
The Regents of the University of California (Oakland, CA)
13/ 225,199
September 2, 2011
STATEMENT OF GOVERNMENTAL SUPPORT This invention was made during work supported by U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.