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Butanol tolerance in microorganisms

United States Patent

March 1, 2016
View the Complete Patent at the US Patent & Trademark Office
Provided herein are recombinant yeast host cells and methods for their use for production of fermentation products from a pyruvate utilizing pathway. Yeast host cells provided herein comprise reduced pyruvate decarboxylase activity and modified adenylate cyclase activity. In embodiments, yeast host cells provided herein comprise resistance to butanol and increased biomass production.
Bramucci; Michael G. (Boothwyn, PA), Nagarajan; Vasantha (Wilmington, DE)
Butamax Advanced Biofuels LLC (Wilmington, DE)
14/ 045,506
October 3, 2013
GOVERNMENT LICENSE RIGHTS This invention was made with Government support under Agreement DE-AR0000006 awarded by the United States Department of Energy. The Government has certain rights in this invention.