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High-stringency screening of target-binding partners using a microfluidic device

United States Patent

December 1, 2015
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
The invention provides a method of screening a library of candidate agents by contacting the library with a target in a reaction mixture under a condition of high stringency, wherein the target includes a tag that responds to a controllable force applied to the tag, and passing the members of the library through a microfluidic device in a manner that exposes the library members to the controllable force, thereby displacing members of the library that are bound to the target relative to their unbound counterparts. Kits and systems for use with the methods of the invention are also provided.
Soh; Hyongsok (Santa Barbara, CA), Lou; Xinhui (Goleta, CA), Lagally; Eric (Vancouver, CA)
The Regents of the University of California (Oakland, CA)
12/ 286,965
October 3, 2008
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with government support under grant no. W-7405-ENG-48 awarded by the Department of Energy. The government has certain rights in the invention.