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L-malate production by metabolically engineered escherichia coli

United States Patent

9,187,772
November 17, 2015
View the Complete Patent at the US Patent & Trademark Office
A process for the production of malic acid in commercially significant quantities from the carbon compounds by genetically modified bacterial strains (GMBS; also referred to as biocatalysts or genetically modified microorganisms) is disclosed. Microorganisms suitable for the production of malic acid can be cultured in one or two-step processes as disclosed herein.
Zhang; Xueli (Tianjin, CN), Wang; Xuan (Gainesville, FL), Shanmugam; Keelnatham T. (Gainesville, FL), Ingram; Lonnie O'Neal (Gainesville, FL)
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, FL)
13/ 819,773
20130157330
September 1, 2011
This invention was made with government support under U.S. Department of Energy Grant No. DE-FG36-08-GO88142). The government has certain rights in the invention.