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Strains for the production of flavonoids from glucose

United States Patent

November 10, 2015
View the Complete Patent at the US Patent & Trademark Office
The invention relates to the production of flavonoids and flavonoid precursors in cells through recombinant expression of tyrosine ammonia lyase (TAL), 4-coumarate:CoA ligase (4CL), chalcone synthase (CHS), and chalcone isomerase (CHI).
Stephanopoulos; Gregory (Winchester, MA), Santos; Christine (Richmond, CA), Koffas; Mattheos (Williamsville, NY)
Massachusetts Institute of Technology (Cambridge, MA), The Research Foundation of State University of New York (Amherst, NY)
13/ 101,462
May 5, 2011
GOVERNMENT INTEREST This invention was made with government support under Grant Nos. DGE0202745, DGE0645960, and CBET0756601 awarded by the National Science Foundation, and under Grant No. DE-FC36-07GO17058 awarded by the Department of Energy. The government has certain rights in this invention.