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Over-expression of NADH-dependent oxidoreductase (fucO) for increasing furfural or 5-hydroxymethylfurfural tolerance

United States Patent

9,157,102
October 13, 2015
View the Complete Patent at the US Patent & Trademark Office
The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in bacterial and/or yeast cells used to produce desired products. Thus, novel biocatalysts (bacterial, fungal or yeast cells) exhibiting increased tolerance to furfural and 5-hydroxymethylfurfural (5-HMF) are provided as are methods of making and using such biocatalysts for the production of a desired product.
Miller; Elliot N. (Indianapolis, IN), Zhang; Xueli (Tianjin, CN), Yomano; Lorraine P. (Gainesville, FL), Wang; Xuan (Gainesville, FL), Shanmugam; Keelnatham T. (Gainesville, FL), Ingram; Lonnie O'Neal (Gainesville, FL)
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (Gainesville, FL)
14/ 008,015
20140024086
March 29, 2012
This invention was made with government support under DE-FG36-080088142 awarded by Department of Energy. The government has certain rights in the invention.