Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
This invention was made with Government support under Contract No. PHS 2 PN2 EY016570B awarded by the National Institute of Health and Contract No. DE-AC04-94AL85000 awarded by the Department of Energy. The U.S. Government has certain rights in the invention.