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Platform for immobilization and observation of subcellular processes

United States Patent

August 26, 2014
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
A method of immobilizing matter for imaging that includes providing an array of nanofibers and directing matter to the array of the nanofibers. The matter is immobilized when contacting at least three nanofibers of the array of nanofibers simultaneously. Adjacent nanofibers in the array of nanofibers may be separated by a pitch as great as 100 microns. The immobilized matter on the array of nanofibers may then be imaged. In some examples, the matter may be cell matter, such as protoplasts.
McKnight; Timothy E. (Greenback, TN), Kalluri; Udaya C. (Knoxville, TN), Melechko; Anatoli V. (Raleigh, NC)
UT-Battelle, LLC (Oak Ridge, TN)
13/ 369,849
February 9, 2012
This invention was made with Government support under Contract No. DE-AC05-000R22725 awarded by the United States Department of Energy. The Government has certain rights in this invention.