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Methods for engineering polypeptide variants via somatic hypermutation and polypeptide made thereby

United States Patent

January 13, 2015
View the Complete Patent at the US Patent & Trademark Office
Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising such vectors.
Tsien; Roger Y. (La Jolla, CA), Wang; Lei (San Diego, CA)
The Regents of the University of California (Oakland, CA)
12/ 124,888
May 21, 2008
GOVERNMENT INTERESTS This invention was made with government support under Grant No. NS27177, awarded by the National Institutes of Health and Grant NO, DE-FG03-01ER63276, awarded by the Department of Energy. The government has certain rights in this invention.