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Semiconductor nanocrystal-based phagokinetic tracking

United States Patent

November 18, 2014
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods for determining metabolic properties of living cells through the uptake of semiconductor nanocrystals by cells. Generally the methods require a layer of neutral or hydrophilic semiconductor nanocrystals and a layer of cells seeded onto a culture surface and changes in the layer of semiconductor nanocrystals are detected. The observed changes made to the layer of semiconductor nanocrystals can be correlated to such metabolic properties as metastatic potential, cell motility or migration.
Alivisatos; A. Paul (Oakland, CA), Larabell; Carolyn A. (Oakland, CA), Parak; Wolfgang J. (Dachau, DE), Le Gros; Mark (Oakland, CA), Boudreau; Rosanne (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
10/ 285,187
October 30, 2002
STATEMENT OF GOVERNMENT SUPPORT This invention was made during work partially supported by U.S. Department of Defense Award No. DAMD17-98-1-8182, DOD Advanced Research Projects Agency (DARPA) under Grant No. N00014-99-1-0728, and the National Institutes of Health under Grant No. 1 R01 RR-14891-01 through the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. The government has certain rights in this invention.