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Parallel macromolecular delivery and biochemical/electrochemical interface to cells employing nanostructures

United States Patent

March 31, 2015
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
Carbon NanoFiber Systems for Tissue Interfacing
Systems and methods are described for parallel macromolecular delivery and biochemical/electrochemical interface to whole cells employing carbon nanostructures including nanofibers and nanotubes. A method includes providing a first material on at least a first portion of a first surface of a first tip of a first elongated carbon nanostructure; providing a second material on at least a second portion of a second surface of a second tip of a second elongated carbon nanostructure, the second elongated carbon nanostructure coupled to, and substantially parallel to, the first elongated carbon nanostructure; and penetrating a boundary of a biological sample with at least one member selected from the group consisting of the first tip and the second tip.
McKnight; Timothy E. (Greenback, TN), Melechko; Anatoli V. (Oak Ridge, TN), Griffin; Guy D. (Oak Ridge, TN), Guillorn; Michael A. (Knoxville, TN), Merkulov; Vladimir L. (Knoxvill, TN), Simpson; Michael L. (Knoxville, TN)
UT-Battelle, LLC (Oak Ridge, TN)
10/ 408,294
April 7, 2003
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY-SPONSORED RESEARCH OR DEVELOPMENT This invention was made with United States Government support under prime contract No. DE-AC05-00OR22725 to UT-Battelle, L.L.C. awarded by the Department of Energy. The Government has certain rights in this invention.