Skip to Content
Find More Like This
Return to Search

Engineering microbes for efficient production of chemicals

United States Patent

April 28, 2015
View the Complete Patent at the US Patent & Trademark Office
This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.
Gong; Wei (Woburn, MA), Dole; Sudhanshu (North Andover, MA), Grabar; Tammy (Reading, MA), Collard; Andrew Christopher (Sommerville, MA), Pero; Janice G. (Lexington, MA), Yocum; R. Rogers (Lexington, MA)
Myriant Corporation (Quincy, MA)
13/ 503,999
November 17, 2010
GOVERNMENT SUPPORT This invention was made with United States Government support under a contract awarded from the US Department of Energy under Award Number DE-EE0002878/001. The United States Government has certain rights in the invention.