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Microfluidic device for acoustic cell lysis

United States Patent

August 4, 2015
View the Complete Patent at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
A microfluidic acoustic-based cell lysing device that can be integrated with on-chip nucleic acid extraction. Using a bulk acoustic wave (BAW) transducer array, acoustic waves can be coupled into microfluidic cartridges resulting in the lysis of cells contained therein by localized acoustic pressure. Cellular materials can then be extracted from the lysed cells. For example, nucleic acids can be extracted from the lysate using silica-based sol-gel filled microchannels, nucleic acid binding magnetic beads, or Nafion-coated electrodes. Integration of cell lysis and nucleic acid extraction on-chip enables a small, portable system that allows for rapid analysis in the field.
Branch; Darren W. (Albuquerque, NM), Cooley; Erika Jane (Albuquerque, NM), Smith; Gennifer Tanabe (Albuquerque, NM), James; Conrad D. (Albuquerque, NM), McClain; Jaime L. (Albuquerque, NM)
Sandia Corporation (Albuquerque, NM)
12/ 872,919
August 31, 2010
STATEMENT OF GOVERNMENT INTEREST This invention was made with Government support under contract no. DE-AC04-94AL85000 awarded by the U. S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention.