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Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents

United States Patent

May 20, 2014
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.
Lee; Soo-Kwan (Seoul, KR), Gang; Oleg (Setauket, NY), van der Lelie; Daniel (Shoreham, NY)
Brookhaven Science Associates, LLC (Upton, NY)
12/ 995,919
June 2, 2009
This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.