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Process and targets for production of no-carrier-added radiotin

United States Patent

April 22, 2014
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
One embodiment of the present invention includes a process for production and recovery of no-carrier-added radioactive tin (NCA radiotin). An antimony target can be irradiated with a beam of accelerated particles forming NCA radiotin, followed by separation of the NCA radiotin from the irradiated target. The target is metallic Sb in a hermetically sealed shell. The shell can be graphite, molybdenum, or stainless steel. The irradiated target can be removed from the shell by chemical or mechanical means, and dissolved in an acidic solution. Sb can be removed from the dissolved irradiated target by extraction. NCA radiotin can be separated from the remaining Sb and other impurities using chromatography on silica gel sorbent. NCA tin-117m can be obtained from this process. NCA tin-117m can be used for labeling organic compounds and biological objects to be applied in medicine for imaging and therapy of various diseases.
Srivastava; Suresh C. (Setauket, NY), Zhuikov; Boris Leonidovich (Moscow region, RU), Ermolaev; Stanislav Victorovich (Moscow region, RU), Konyakhin; Nikolay Alexandrovich (Kaluga region, RU), Kokhanyuk; Vladimir Mikhailovich (Moscow region, RU), Khamyanov; Stepan Vladimirovich (Kaluga region, RU), Togaeva; Natalya Roaldovna (Kaluga region, RU)
Brookhaven Science Associates, LLC (N/A)
11/ 962,851
December 21, 2007
GOVERNMENT RIGHTS This invention was made with government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy, and Research Program of Russian Academy of Sciences #01.2.00 305488. The U.S. Government has certain rights in the invention.