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Personal glucose meters for detection and quantification of a broad range of analytes

United States Patent

February 3, 2015
View the Complete Patent at the US Patent & Trademark Office
A general methodology for the development of highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method uses recognition molecules that are specific for a target agent, enzymes that can convert an enzyme substrate into glucose, and PGM. Also provided are sensors, which can include a solid support to which is attached a recognition molecule that permits detection of a target agent, wherein the recognition molecule specifically binds to the target agent in the presence of the target agent but not significantly to other agents as well as an enzyme that can catalyze the conversion of a substance into glucose, wherein the enzyme is attached directly or indirectly to the recognition molecule, and wherein in the presence of the target agent the enzyme can convert the substance into glucose. The disclosed sensors can be part of a lateral flow device. Methods of using such sensors for detecting target agents are also provided.
Lu; Yi (Champaign, IL), Xiang; Yu (Urbana, IL)
The Board of Trustees of the University of Illinois (Urbana, IL)
13/ 699,578
May 26, 2011
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT This invention was made with government support under DE-FG02-08ER64568 awarded by the US Department of Energy, under ES16865 awarded by the National Institutes of Health, and CTS-0120978 awarded by the National Science Foundation. The government has certain rights in the invention.