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Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease

United States Patent

September 30, 2014
View the Complete Patent at the US Patent & Trademark Office
Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with .sup.18F, .sup.123I, or .sup.124I, or free hexoses radiolabeled with .sup.18F, .sup.123I, or .sup.124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.
Wright; Ernest M. (Los Angeles, CA), Barrio; Jorge R. (Agoura Hills, CA), Hirayama; Bruce A. (Los Angeles, CA), Kepe; Vladimir (Los Angeles, CA)
The Regents of the University of California (Oakland, CA)
11/ 920,904
May 23, 2006
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT This application was made with government support under Grant No. DK19567 (E. Wright), awarded by the National Institutes of Health, UCLA discretionary funds (E. Wright), and DE-FC03-02ER63-420, awarded by the Department of Energy (J. Barrio). The Government has certain rights in the invention.