Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with .sup.18F, .sup.123I, or .sup.124I, or free hexoses radiolabeled with .sup.18F, .sup.123I, or .sup.124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT
This application was made with government support under Grant No. DK19567 (E. Wright), awarded by the National Institutes of Health, UCLA discretionary funds (E. Wright), and DE-FC03-02ER63-420, awarded by the Department of Energy (J. Barrio). The Government has certain rights in the invention.