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Devices, systems, and methods for conducting sandwich assays using sedimentation

United States Patent

February 3, 2015
View the Complete Patent at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
Schaff; Ulrich Y. (Davis, CA), Sommer; Gregory J. (Livermore, CA), Singh; Anup K. (Danville, CA), Hatch; Anson V. (Tracy, CA)
Sandia Corporation (Albuquerque, NM)
12/ 891,977
September 28, 2010
STATEMENT REGARDING RESEARCH & DEVELOPMENT Described examples were made with Government support under Government Contract No. DE-AC04-94AL85000 awarded by the U.S. Department of Energy to Sandia Corporation. The Government has certain rights in the invention, including a paid-up license and the right, in limited circumstances, to require the owner of any patent issuing in this invention to license others on reasonable terms.