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Methods and kits for predicting a response to an erythropoietic agent

United States Patent

June 16, 2015
View the Complete Patent at the US Patent & Trademark Office
Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent. Kits for predicting a response to an erythropoietic agent are further provided and include one or more antibodies, or fragments thereof, that specifically recognize a peptide of SEQ ID NOS: 1-17.
Merchant; Michael L. (Louisville, KY), Klein; Jon B. (Louisville, KY), Brier; Michael E. (New Albany, IN), Gaweda; Adam E. (Louisville, KY)
University of Louisville Research Foundation, Inc. (Louisville, KY)
13/ 167,478
June 23, 2011
GOVERNMENT INTEREST This invention was made with U.S. Government support under Grant Numbers P30ES014443, DK085673-01, DK077331, and DK072085 awarded by the National Institutes of Health; Grant Number DE-FG02-05ER6406 awarded by the U.S. Department of Energy; and individual Merit Awards awarded by the Department of Veterans Affairs to Drs. Michael E. Brier and Jon B. Klein. The government has certain rights in this invention.