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Methods for threshold determination in multiplexed assays

United States Patent

June 24, 2014
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Methods for determination of threshold values of signatures comprised in an assay are described. Each signature enables detection of a target. The methods determine a probability density function of negative samples and a corresponding false positive rate curve. A false positive criterion is established and a threshold for that signature is determined as a point at which the false positive rate curve intersects the false positive criterion. A method for quantitative analysis and interpretation of assay results together with a method for determination of a desired limit of detection of a signature in an assay are also described.
Tammero; Lance F. Bentley (Oakland, CA), Dzenitis; John M. (Danville, CA), Hindson; Benjamin J. (Livermore, CA)
Lawrence Livermore National Security, LLC (Livermore, CA)
12/ 607,956
October 28, 2009
STATEMENT OF GOVERNMENT GRANT The U.S. Government has certain rights in this invention pursuant to Contract No. W-7405-ENG-48 between the U.S. Department of Energy and the University of California.