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Uses of monoclonial antibody 8H9

United States Patent

9,062,110
June 23, 2015
View the Complete Patent at the US Patent & Trademark Office
This invention provides an antibody that binds the same antigen as that of monoclonal antibody 8H9, wherein the heavy chain CDR (Complementary Determining Region)1 comprises NYDIN, heavy chain CDR2 comprises WIFPGDGSTQY, heavy chain CDR3 comprises QTTATWFAY, and the light chain CDR1 comprises RASQSISDYLH, light chain CDR2 comprises YASQSIS, and light chain CDR3 comprises QNGHSFPLT. In another embodiment, there is provided a polypeptide that binds the same antigen as that of monoclonal antibody 8H9, wherein the polypeptide comprises NYDIN, WIFPGDGSTQY, QTTATWFAY, RASQSISDYLH, YASQSIS, and QNGHSFPLT.
Cheung; Nai-Kong V. (New York, NY)
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (New York, NY)
13/ 858,234
20130287798
April 8, 2013
The invention disclosed herein was made with government support under Department of Energy Grant No. DE-FG-02-93ER61658 (1997-2002), the National Cancer Institute Grant No. NCI CA 89936 (12/1/00-11/30/02), and National Institutes of Health Grant No. CA61017. Accordingly, the U.S. Government has certain rights in this invention.