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Radio-methyl vorozole and methods for making and using the same

United States Patent

August 5, 2014
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same are provided. [N-radio-methyl] vorozole substantially separated from an N-3 radio-methyl isomer of vorozole is provided. Separation is accomplished through use of chromatography resins providing multiple mechanisms of selectivity.
Kim; Sung Won (Port Jefferson, NY), Biegon; Anat (Port Jefferson, NY), Fowler; Joanna S. (Bellport, NY)
Brookhaven Science Associates, LLC (Upton, NY)
12/ 704,114
February 11, 2010
This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy and sponsored by the National Institutes of Health under grant number KO5 DA 020001. The Government has certain rights in the invention.