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Amphiphiles for protein solubilization and stabilization

United States Patent

8,877,906
November 4, 2014
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Gellman; Samuel Helmer (Madison, WI), Chae; Pil Seok (Madison, WI), Laible; Phillip D. (Villa Park, IL), Wander; Marc J. (Downers Grove, IL)
Wisconsin Aumni Research Foundation (Madison, WI), UChicago Argonne, LLC (Chicago, IL)
13/ 608,385
20130001465
September 10, 2012
GOVERNMENT SUPPORT This invention was made with government support under W-31-109-ENG38 awarded by the US Department of Energy. The government has certain rights in the invention.