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Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

United States Patent

8,784,866
July 22, 2014
View the Complete Patent at the US Patent & Trademark Office
Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.
Tour; James M. (Bellaire, TX), Lucente-Schultz; Rebecca (Houston, TX), Leonard; Ashley (Houston, TX), Kosynkin; Dmitry V. (Houston, TX), Price; Brandi Katherine (Houston, TX), Hudson; Jared L. (Hamilton, VA), Conyers, Jr.; Jodie L. (Houston, TX), Moore; Valerie C. (Houston, TX), Casscells; S. Ward (Houston, TX), Myers; Jeffrey N. (Houston, TX), Milas; Zvonimir L. (Houston, TX), Mason; Kathy A. (Houston, TX), Milas; Luka (Houston, TX)
William Marsh Rice University (Houston, TX), Board of Regents, The University of Texas System (Austin, TX)
12/ 245,438
20090170768
October 3, 2008
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with government support under Grant No. DE-FC36-05GO15073, awarded by the U.S. Department of Energy; Grant No. NNJ06HE06A, awarded by the National Aeronautics and Space Administration; Grant No. NNJ06HI25A, awarded by the National Aeronautics and Space Administration; Grant No. NNJ05HE75A , awarded by the National Aeronautics and Space Administration; and Grant No. HR0011-08-1-0010, awarded by the U.S. Department of Defense. The Government has certain rights in the invention.