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Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling

United States Patent

August 4, 2015
View the Complete Patent at the US Patent & Trademark Office
A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.
Olma; Sebastian (Muenster, DE), Shen; Clifton Kwang-Fu (Archerfield, AU)
The Regents Of The University Of California (Oakland, CA)
13/ 924,397
June 21, 2013
This invention was made with Government support under CA086306, awarded by the National Institutes of Health; DE-FG02-06ER64249, awarded by the United States Department of Energy. The Government has certain rights in this invention.