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Medical implants and methods of making medical implants

United States Patent

September 16, 2014
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
Shaw; Wendy J. (Richland, WA), Yonker; Clement R. (Kennewick, WA), Fulton; John L. (Richland, WA), Tarasevich; Barbara J. (Richland, WA), McClain; James B. (Raleigh, NC), Taylor; Doug (Franlinton, NC)
Battelle Memorial Institute (Richland, WA)
12/ 648,106
December 28, 2009
GOVERNMENT RIGHTS This invention was made with Government support under contract DE-AC0676RLO-1830, awarded by the U.S. Department of Energy. The Government has certain rights in this invention.