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3D and 4D magnetic susceptibility tomography based on complex MR images

United States Patent

November 11, 2014
View the Complete Patent at the US Patent & Trademark Office
Magnetic susceptibility is the physical property for T2*-weighted magnetic resonance imaging (T2*MRI). The invention relates to methods for reconstructing an internal distribution (3D map) of magnetic susceptibility values, .chi. (x,y,z), of an object, from 3D T2*MRI phase images, by using Computed Inverse Magnetic Resonance Imaging (CIMRI) tomography. The CIMRI technique solves the inverse problem of the 3D convolution by executing a 3D Total Variation (TV) regularized iterative convolution scheme, using a split Bregman iteration algorithm. The reconstruction of .chi. (x,y,z) can be designed for low-pass, band-pass, and high-pass features by using a convolution kernel that is modified from the standard dipole kernel. Multiple reconstructions can be implemented in parallel, and averaging the reconstructions can suppress noise. 4D dynamic magnetic susceptibility tomography can be implemented by reconstructing a 3D susceptibility volume from a 3D phase volume by performing 3D CIMRI magnetic susceptibility tomography at each snapshot time.
Chen; Zikuan (Albuquerque, NM), Calhoun; Vince D. (Albuquerque, NM)
STC.UNM (Albuquerque, NM)
13/ 526,210
June 18, 2012
FEDERALLY SPONSORED RESEARCH The United States Government has rights in this invention pursuant to Department of Energy Contract No. DE-FG02-08ER64581 with the Mind Research Network; and pursuant to the National Institutes of Health Contract Nos. R01 EB005846 and R01 EB006841 with the University of New Mexico, Electrical and Computer Engineering Department.