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Pnp gene modification for improved xylose utilization in Zymomonas

United States Patent

December 16, 2014
View the Complete Patent at the US Patent & Trademark Office
The endogenous pnp gene encoding polynucleotide phosphorylase in the Zymomonas genome was identified as a target for modification to provide improved xylose utilizing cells for ethanol production. The cells are in addition genetically modified to have increased expression of ribose-5-phosphate isomerase (RPI) activity, as compared to cells without this genetic modification, and are not limited in xylose isomerase activity in the absence of the pnp modification.
Caimi; Perry G G (Kennett Square, PA), Qi; Min (Hockessin, DE), Tao; Luan (Wallingford, PA), Viitanen; Paul V (West Chester, PA), Yang; Jianjun (Hockessin, DE)
E I Du Pont de Nemours and Company (Wilmington, DE)
13/ 711,646
December 12, 2012
STATEMENT OF GOVERNMENT RIGHTS This invention was made with United States government support under Contract No. DE-FC36-07GO17056 awarded by the Department of Energy. The government has certain rights in this invention.