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Plume collimation for laser ablation electrospray ionization mass spectrometry

United States Patent

September 9, 2014
View the Complete Patent at the US Patent & Trademark Office
In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.
Vertes; Akos (Reston, VA), Stolee; Jessica A. (Washington, DC)
The George Washington University (Washington, DC)
13/ 549,988
July 16, 2012
STATEMENT OF GOVERNMENTAL INTEREST This invention was made with Government support under Grant No. 0719232 awarded by the National Science Foundation and Grant No. DEFG02-01ER15129 awarded by the U.S. Department of Energy. The government has certain rights in the invention