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Materials and methods for efficient succinate and malate production

United States Patent

April 8, 2014
View the Complete Patent at the US Patent & Trademark Office
Genetically engineered microorganisms have been constructed to produce succinate and malate in mineral salt media in pH-controlled batch fermentations without the addition of plasmids or foreign genes. The subject invention also provides methods of producing succinate and malate comprising the culture of genetically modified microorganisms.
Jantama; Kaemwich (Gainesville, FL), Haupt; Mark John (Pace, FL), Zhang; Xueli (Gainesville, FL), Moore; Jonathan C. (Gainesville, FL), Shanmugam; Keelnatham T. (Gainesville, FL), Ingram; Lonnie O'Neal (Gainesville, FL)
University of Florida Research Foundation, Inc. (Gainesville, FL)
12/ 529,826
March 19, 2008
GOVERNMENT SUPPORT This invention was made with government support under a grant awarded from the Department of Energy under grant number USDOE-DE FG02-96ER20222 and Department of Energy in conjunction with the United States Department of Agriculture under grant number USDA & DOE Biomass RDI DE FG36-04GO14019. The government has certain rights in the invention.