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Pantothenic acid biosynthesis in zymomonas

United States Patent

July 1, 2014
View the Complete Patent at the US Patent & Trademark Office
Zymomonas is unable to synthesize pantothenic acid and requires this essential vitamin in growth medium. Zymomonas strains transformed with an operon for expression of 2-dehydropantoate reductase and aspartate 1-decarboxylase were able to grow in medium lacking pantothenic acid. These strains may be used for ethanol production without pantothenic acid supplementation in seed culture and fermentation media.
Tao; Luan (Wallingford, PA), Tomb; Jean-Francois (Wilmington, DE), Viitanen; Paul V. (West Chester, PA)
E I du Pont de Nemours and Company (Wilmington, DE)
13/ 433,343
March 29, 2012
STATEMENT OF GOVERNMENT RIGHTS This invention was made with United States government support under Contract No. DE-FC36-07GO17056 awarded by the Department of Energy. The government has certain rights in this invention.