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Subcellular analysis by laser ablation electrospray ionization mass spectrometry

United States Patent

8,901,487
December 2, 2014
View the Complete Patent at the US Patent & Trademark Office
In various embodiments, a method of laser ablation electrospray ionization mass spectrometry (LAESI-MS) may generally comprise micro-dissecting a cell comprising at least one of a cell wall and a cell membrane to expose at least one subcellular component therein, ablating the at least one subcellular component by an infrared laser pulse to form an ablation plume, intercepting the ablation plume by an electrospray plume to form ions, and detecting the ions by mass spectrometry.
Vertes; Akos (Reston, VA), Stolee; Jessica A. (Washington, DC), Shrestha; Bindesh (Arlington, VA)
George Washington University (Washington, DC)
13/ 045,277
20110215233
March 10, 2011
STATEMENT OF GOVERNMENTAL INTEREST Portions of this invention were made with United States government support under Grant No. 0719232 awarded by the National Science Foundation and Grant No. DEFG02-01ER15129 awarded by the Department of Energy. The government has certain rights in the invention.