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Isothermal amplification of DNA

United States Patent

April 29, 2014
View the Complete Patent at the US Patent & Trademark Office
A method of amplifying a template DNA molecule comprising incubating the template DNA molecule in a reaction mixture comprising a DNA polymerase and at least one accessory protein at a constant temperature to produce amplified product, wherein production of amplified product does not require exogenously-added oligonucleotide primers and the template DNA molecule does not have have terminal protein covalently bound to either 5' end.
Tabor; Stanley (Brookline, MA), Richardson; Charles C. (Newton, MA)
President and Fellows of Harvard College (Cambridge, MA)
10/ 813,693
November 7, 2003
This invention was made with government support including a grant from the U.S. Dept. of Energy, contract number DE-FG02-96ER62251. The U.S. government may have certain rights in the invention.