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Cellulase variants

United States Patent

9,080,162
July 14, 2015
View the Complete Patent at the US Patent & Trademark Office
This invention provides novel variant cellulolytic enzymes having improved activity and/or stability. In certain embodiments the variant cellulotyic enzymes comprise a glycoside hydrolase with or comprising a substitution at one or more positions corresponding to one or more of residues F64, A226, and/or E246 in Thermobifida fusca Cel9A enzyme. In certain embodiments the glycoside hydrolase is a variant of a family 9 glycoside hydrolase. In certain embodiments the glycoside hydrolase is a variant of a theme B family 9 glycoside hydrolase.
Blazej; Robert (San Francisco, CA), Toriello; Nicholas (Woodside, CA), Emrich; Charles (San Francisco, CA), Cohen; Richard N. (Oakland, CA), Koppel; Nitzan (Sunnyvale, CA)
Novozymes, A/S (Bagsvaerd, DK)
14/ 111,321
20140113335
April 11, 2012
STATEMENT OF GOVERNMENTAL SUPPORT This work was supported in part by Grant No DE-SC0002302 from the Department of Energy. The Government has certain rights in this invention.