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Producing dicarboxylic acids using polyketide synthases

United States Patent

October 29, 2013
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.
Katz; Leonard (Oakland, CA), Fortman; Jeffrey L (San Francisco, CA), Keasling; Jay D (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
12/ 922,204
March 30, 2009
STATEMENT OF GOVERNMENTAL SUPPORT This invention was made with government support under Contract No. DE-AC02-05 CH11231 awarded by the U.S. Department of Energy and under Award No. 0540879awarded by the National Science Foundation. The government has certain rights in the invention.