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Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof

United States Patent

March 11, 2014
View the Complete Patent at the US Patent & Trademark Office
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
Anderson; J. Christopher (San Francisco, CA), Wu; Ning (Brookline, MA), Santoro; Stephen (Cambridge, MA), Schultz; Peter G. (La Jolla, CA)
The Scripps Research Institute (La Jolla, CA)
13/ 246,490
September 27, 2011
This invention was made with government support under grant number GM62159 from the National Institutes of Health, and grant number ER45812 from the Department of Energy. The United States Government has certain rights in this invention.