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Transformation of gram positive bacteria by sonoporation

United States Patent

March 11, 2014
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
Universal Gene Transfer Technology for Gram Positive Bacteria
The present invention provides a sonoporation-based method that can be universally applied for delivery of compounds into Gram positive bacteria. Gram positive bacteria which can be transformed by sonoporation include, for example, Bacillus, Streptococcus, Acetobacterium, and Clostridium. Compounds which can be delivered into Gram positive bacteria via sonoporation include nucleic acids (DNA or RNA), proteins, lipids, carbohydrates, viruses, small organic and inorganic molecules, and nano-particles.
Yang; Yunfeng (Oak Ridge, TN), Li; Yongchao (Oak Ridge, TN)
UT-Battelle, LLC (Oak Ridge, TN)
12/ 657,885
January 29, 2010
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under Contract Number DE-AC05-000R22725 between the United States Department of Energy and UT-Battelle, LLC. The United States government has certain rights in this invention.