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Nucleic acid molecules conferring enhanced ethanol tolerance and microorganisms having enhanced tolerance to ethanol

United States Patent

January 14, 2014
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
Microorganisms to Speed Production of Biofuels
The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified microorganisms for production of biofuels based on fermentation of biomass materials.
Brown; Steven (Knoxville, TN), Guss; Adam (Knoxville, TN), Yang; Shihui (Knoxville, TN), Karpinets; Tatiana (Louisville, TN), Lynd; Lee (Meriden, NH), Shao; Xiongjun (White River Junction, VT)
UT-Battelle, LLC (Oak Ridge, TN)
13/ 112,641
May 20, 2011
This invention was made with government support under Contract Number DE-AC05-00OR22725 between the United States Department of Energy and UT-Battelle, LLC. The U.S. Government has certain rights in this invention.