The present invention relates to compositions, devices and methods for detecting microorganisms (e.g., anthrax). In particular, the present invention provides portable, surface-enhanced Raman biosensors, and associated substrates, and methods of using the same, for use in rapidly detecting and identifying microorganisms (e.g., anthrax).
This invention was made with government support under DMR-0076097, DMR-0520519, DMR-0520513, EEC-0118025 and CHE-0414554 awarded by the National Science Foundation, under F49620-02-1-0381 awarded by the Air Force Office of Scientific Research MURI, and under DE-FG02-03ER15457 awarded by the U.S. Department of Energy. The government has certain rights in the invention. The United States Government has rights in this invention pursuant to Contract No. W-31-109-ENG-38 between the United States Government and The University of Chicago and/or pursuant to Contract No. DE-AC02-06CH11357 between the United States Government and UChicago Argonne, LLC representing Argonne National Laboratory.