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Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules

United States Patent

January 14, 2014
View the Complete Patent at the US Patent & Trademark Office
Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distinct forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.
Adamec; Jiri (West Lafayette, IN), Yang; Wen-Chu (West Lafayette, IN), Regnier; Fred E. (West Lafayette, IN)
Purdue Research Foundation (West Lafayette, IN)
12/ 990,560
May 1, 2009
GOVERNMENT FUNDING This invention was made with government support under Grant No. R33DK070290, awarded by the National Institutes of Health, Grant No. DE-FC36-07GO17059, awarded by the U.S. Department of Energy, and Grant No. DBI0421102, awarded by the National Science Foundation. The Government has certain rights in the invention.