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Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells

United States Patent

February 25, 2014
View the Complete Patent at the US Patent & Trademark Office
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
Zhang; Zhiwen (San Diego, CA), Alfonta; Lital (San Diego, CA), Schultz; Peter G. (La Jolla, CA)
The Scripps Research Institute (La Jolla, CA)
13/ 546,582
July 11, 2012
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with Government support under Contract Number DE-FG03-00ER45812 awarded by the Department of Energy, and Contract Number NIH GM066494 awarded by the National Institutes of Health. Therefore, the United States government has certain rights in this invention.