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Fatty acid-producing hosts

United States Patent

December 31, 2013
View the Complete Patent at the US Patent & Trademark Office
Described are hosts for overproducing a fatty acid product such as a fatty acid. The hosts include an exogenous nucleic acid encoding a thioesterase and, optionally, an exogenous nucleic acid encoding an acetyl-CoA carboxylase, wherein an acyl-CoA synthetase in the hosts are functionally deleted. The hosts preferably include the nucleic acid encoding the thioesterase at an intermediate copy number. The hosts are preferably recombinantly stable and growth-competent at C. Methods of producing a fatty acid product comprising culturing such hosts at C. are also described.
Pfleger; Brian F. (Madison, WI), Lennen; Rebecca M. (Madison, WI)
Wisconsin Alumni Research Foundation (Madison, WI)
12/ 984,343
January 4, 2011
FEDERAL FUNDING STATEMENT This invention was made with government support under DE-FC02-07ER64494 and DE-FG02-03ER15468 awarded by the US Department of Energy. The government has certain rights in the invention.