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In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris

United States Patent

8,647,840
February 11, 2014
View the Complete Patent at the US Patent & Trademark Office
The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris. Methods for producing polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris are also provided.
Young; Travis (San Diego, CA), Schultz; Peter G. (La Jolla, CA)
The Scripps Research Institute (La Jolla, CA)
12/ 734,995
20110014650
December 10, 2008
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT The invention was made with government support under Contract No. GM062159 awarded by the National Institutes of Health and under DE-FG03-00ER46051 awarded by the Department of Energy. The government has certain rights in this invention.