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Rapid classification of biological components

United States Patent

October 15, 2013
View the Complete Patent at the US Patent & Trademark Office
Idaho National Laboratory - Visit the Technology Transfer and Commercialization Office Website
A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.
Thompson; Vicki S. (Idaho Falls, ID), Barrett; Karen B. (Meridian, ID), Key; Diane E. (Idaho Falls, ID)
United States Department of Energy (Washington, DC)
13/ 425,181
March 20, 2012
CONTRACTUAL ORIGIN OF THE INVENTION This invention was made with government support under Contract No. DE-AC07-941D13223, Contract No. DE-AC07-991D13727, and DE-AC07-051D14517 awarded by the United States Department of Energy. The government has certain rights in the invention.