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Detection of magnetic resonance signals using a magnetoresistive sensor

United States Patent

October 1, 2013
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.
Budker; Dmitry (El Cerrito, CA), Pines; Alexander (Berkeley, CA), Xu; Shoujun (Houston, TX), Hilty; Christian (College Station, TX), Ledbetter; Micah P. (Oakland, CA), Bouchard; Louis S. (Los Angeles, CA)
The Regents of the University of California (Oakland, CA)
12/ 753,306
April 2, 2010
STATEMENT OF GOVERNMENTAL SUPPORT The invention described and claimed herein was made in part utilizing funds supplied by the U.S. Department of Energy under Contracts No. DE-AC03-76SF00098, and DE-AC02-05CH11231 with the Regents of the University of California for the management and operation of the Lawrence Berkeley National Laboratory. The government has certain rights in this invention.